![]() ![]() Lastly, antibody detection can help select appropriate individuals for clinical trials for vaccine or therapy development.ĪM: In the case of SARS-CoV-2, most serology tests are based on detecting antibodies against either the N protein or the S protein. Furthermore, these assays can identify individuals who can be donors of convalescent plasma to treat infected individuals. ![]() Serological assays are helpful in conducting epidemiologic studies to evaluate the extent of virus spread in communities and to determine infection fatality rate. Antibody detection in combination with RT-PCR expands the detection window of SARS-CoV-2 infection and minimizes false-negative RT-PCR testing. However, detection of antibodies against SARS-CoV-2 virus complements viral testing. Therefore, these tests cannot be used to detect acute infections. Serological testing helps to understand the immune responses to SARS-CoV-2 in a dynamic qualitative manner and to identify individuals who were exposed to the virus.Īnti-SARS-CoV-2 antibodies can be detected in blood as early as 10 days after the onset of clinical symptoms. Iswariya Venkataraman (IV): Once there is contact with SARS-CoV-2, the immune system produces antibodies against this virus. Iswariya also discussed the findings and implications from the study, which cautioned against the extensive use of tests that detect antibodies against the N protein only.Īnna MacDonald (AM): Can you provide our readers with an overview of serology tests, what they detect, and how this information can be used? Technology Networks spoke to Dr Iswariya Venkataraman, Scientific Affairs Lead at EUROIMMUN US, to learn about the differences between the S and N proteins and what makes them suitable as target antigens in serology testing. ![]() Some detect the presence of antibodies against the spike (S) protein, while others detect antibodies against the nucleocapsid (N) protein. However, findings from a study recently published in JCI Insight suggest that the information which can be inferred from a positive antibody test may depend on the specific antibodies that the test detects. Several tests have already been developed which can detect antibodies against SARS-CoV-2 and identify individuals who have experienced prior infection with the virus. Throughout the COVID-19 pandemic, researchers have been working tirelessly to understand the human immune response to SARS-CoV-2, including the duration and level of protection that antibodies may provide against re-infection. ![]()
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